Has your psoriasis gotten worse after starting Skyrizi?
It's understandably concerning when symptoms seem to worsen shortly after starting a new treatment. While Skyrizi (risankizumab) has shown good results for many people with psoriasis, it's important to know that biologic medications typically take time to work.
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Has your psoriasis gotten worse after starting Skyrizi?
It's understandably concerning when symptoms seem to worsen shortly after starting a new treatment. While Skyrizi (risankizumab) has shown good results for many people with psoriasis, it's important to know that biologic medications typically take time to work.
Most people don't see improvements within just a few days of starting treatment. The medication needs time to build up in your system and begin blocking the inflammation that causes psoriasis symptoms.
In clinical trials, meaningful improvements were typically seen after several weeks of treatment, not within the first few days. What you're experiencing could be:
- Your natural psoriasis cycle continuing before the medication has had time to take effect
- A flare-up triggered by other factors like stress, weather changes, or other triggers
- Initial adjustment as your body responds to the new medication
You should contact your dermatologist right away to discuss your worsening symptoms. They can evaluate whether this is expected during the early treatment phase or if you're experiencing a reaction that needs attention. Don't wait to reach out - they need to know how you're responding to the treatment, especially this early on.
November 19, 2025
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