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Real members of MyPsoriasisTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A MyPsoriasisTeam Member asked a question 💭
Manchester, UK

Anyone tried SOTYKTU®
(deucravacitinib)? And how did you react to it?. I'm awaiting the treatment which I've never tried. Fingers crossed .🤔

January 19
 · 
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MyPsoriasisTeam

What are the risks and side effects of Sotyktu (deucravacitinib)?

Sotyktu can cause several side effects, though serious ones were rare in clinical trials. Here's what to watch for:

Most common side effects include
* More frequent infections (upper respiratory infections, herpes simplex)
* Mouth sores
* Acne
* Show Full Answer

What are the risks and side effects of Sotyktu (deucravacitinib)?

Sotyktu can cause several side effects, though serious ones were rare in clinical trials. Here's what to watch for:

Most common side effects include:
* More frequent infections (upper respiratory infections, herpes simplex)
* Mouth sores
* Acne
* Folliculitis (inflammation or itching of hair follicles)
* High blood creatine phosphokinase levels (may indicate muscle breakdown)

Serious side effects (rare):
* Serious infections like pneumonia
* Pericarditis (heart tissue inflammation)
* Cholecystitis (gallbladder inflammation)
* Lymphoma (occurred in 3 people across all trials)

Important monitoring:
Before starting Sotyktu, you'll need testing for tuberculosis and hepatitis. Your doctor should monitor your triglyceride levels while on the medication, and liver enzymes if you have any liver concerns. You shouldn't receive live vaccines while taking it.

The good news is that serious side effects occurred less often with Sotyktu compared to some other treatments in studies. How effective is Sotyktu?

Clinical trials showed promising results. After 24 weeks:
* 60-70% of people achieved 75% improvement in their psoriasis
* 30-40% achieved 90% improvement
* 50-60% had clear or almost clear skin

These results were long-lasting, with 4 out of 5 people maintaining their improvement after one year.

Best of luck with your new treatment! Many members have found success with it, and fingers crossed you'll be one of them. Track any new symptoms and keep your dermatologist updated on how you're doing.

January 19

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