Starting methotrexate and trying to keep up with a full-time job is genuinely tough — and that early-week exhaustion is a very real and common experience. Fatigue is one of the most frequently reported side effects of methotrexate, so what you're feeling makes complete sense.
Many MyPsoriasisTeam members describe pushing Show Full Answer
Starting methotrexate and trying to keep up with a full-time job is genuinely tough — and that early-week exhaustion is a very real and common experience. Fatigue is one of the most frequently reported side effects of methotrexate, so what you're feeling makes complete sense.
Many MyPsoriasisTeam members describe pushing through workdays feeling drained, with one sharing: "Still fatigued. At work, trying to give it a go." Another noted taking a day off mid-week just to recover enough to function the rest of the week. Here are some strategies that may help manage fatigue while working:
- Start light — gentle movement or short walks can actually help with energy levels
- Eat well — lean proteins, whole grains, and fresh fruit and vegetables can support your energy
- Ask your doctor about supplements — Vitamin D or B vitamins may help with fatigue (your doctor may already have you on folic acid with methotrexate)
- Rest strategically — spread out tasks and take breaks when possible
- Keep a fatigue diary — tracking when you feel worst, what you ate, and how you slept can help identify patterns
It's also worth talking to your doctor about the timing of your methotrexate dose — sometimes splitting the dose can reduce side effects. If fatigue continues to seriously impact your work and daily life, that's an important conversation to have with your doctor too.
August 25
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