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Humira (adalimumab) is a biologic medication approved by the U.S. Food and Drug Administration (FDA) for treating moderate to severe psoriasis in adults.
These insights are based on 906 comments about Humira from MyPsoriasisTeam members. These are the experiences of a small number of members and are not meant to be medical advice.
Humira works by blocking tumor necrosis factor-alpha (TNF-alpha), a protein that causes inflammation in psoriasis. TNF-alpha is naturally produced by your immune system but can become overactive in autoimmune conditions like psoriasis.
By blocking TNF-alpha activity, Humira helps decrease the rapid skin cell growth and inflammation that creates psoriatic plaques. These plaques appear as raised, red patches covered with silvery-white scales on lighter skin tones or as purple-brown patches with gray scales on darker skin tones.
Doctors prescribe Humira when psoriasis significantly affects quality of life and hasn’t responded well to other treatments. The medication is given as an injection under the skin, which healthcare providers will teach you to do at home.
These insights are based on 906 comments about Humira from MyPsoriasisTeam members.Members emphasize the importance of tracking symptoms daily and being prepared for potential side effects, particularly the increased risk of infections. Many find that patience is crucial, as results can take months to appear.
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MyPsoriasisTeam members have described some side effects from taking Humira. According to the prescribing information, the most common side effects in people treated for psoriasis are similar to those seen in other conditions treated with Humira. These include:
In psoriasis trials for Humira, one difference stood out: Joint pain occurred for about 3 percent of people with psoriasis compared to 1 percent of those on placebo (an inactive treatment).
Serious side effects require immediate medical attention. Rare but serious side effects associated with Humira include:
Always let your doctor know about any new or worsening symptoms when taking Humira.
Humira Complete is the manufacturer’s assistance program that may help eligible people pay little or no money per month. Eligibility requirements apply — visit the website or call 800-4HUMIRA for details.
People without private insurance coverage may qualify for other patient assistance programs. Speak with your healthcare provider about coverage options and financial assistance.
Before starting Humira, you’ll need several important health checks. These include:
Your doctor may also ask about past infections, where you’ve lived or traveled, and your overall health before prescribing Humira. Be sure to inform your doctor about any other medications you are taking. Other biologics like anakinra or abatacept may increase infection risk. You should also avoid live vaccines while taking Humira.
Humira is also FDA-approved to treat psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, Crohn’s disease, ulcerative colitis, hidradenitis suppurativa, and certain types of uveitis.
If you miss a dose, take it as soon as you remember and continue your regular schedule. Discuss pregnancy or breastfeeding plans with your doctor before starting treatment.
These answers are fact-checked by our editorial staff.
How effective is Humira for treating psoriasis plaques?
In clinical trials, 71 percent of adults saw at least a 75 percent improvement in their psoriasis symptoms after 16 weeks of Humira treatment, compared to 7 percent taking placebo (an inactive treatment).
How long does Humira typically take to improve psoriasis symptoms?
According to clinical trial data, many people begin seeing improvement within 16 weeks, though individual responses vary significantly.
What specific infections should I watch for while taking Humira?
Humira can raise your risk of infections. Common ones include colds, sinus infections, and other upper respiratory infections. More serious infections can also occur, such as tuberculosis, fungal infections (like histoplasmosis), or infections from bacteria like listeria or legionella. Call your doctor right away if you develop fever, persistent cough, unusual tiredness, or any signs of infection.
Can I take other psoriasis medications while using Humira?
Avoid live vaccines, and use caution with biologics like anakinra or abatacept. Always discuss all medications with your healthcare provider before combining treatments.
On MyPsoriasisTeam, people share their experiences with psoriasis, get advice, and find support from others who understand.
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