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Tremfya (guselkumab) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for treating moderate to severe plaque psoriasis in adults who may benefit from injections, pills, or light therapy.
These insights are based on 388 comments about Tremfya from MyPsoriasisTeam members. These are the experiences of a small number of members and are not meant to be medical advice.
Tremfya is a human monoclonal antibody that blocks a protein called interleukin (IL)-23. This protein plays a role in the inflammation that causes psoriasis and other conditions. By blocking IL-23, Tremfya can help reduce the rapid skin cell growth that leads to psoriasis plaques — raised, scaly patches that look red or pink on lighter skin and dark brown or purple on darker skin.
Doctors may prescribe Tremfya for adults and children 6 years and older with moderate to severe plaque psoriasis. The medication is given as an injection under the skin at specific intervals — your doctor will determine the exact schedule for you. Most people will receive the injections every eight weeks.
These insights are based on 388 comments about Tremfya from MyPsoriasisTeam members.MyPsoriasisTeam members who’ve used Tremfya report mixed experiences. Many found it effective for skin clearance though results can take several months to appear. Common side effects like headache and increased infection risk are generally manageable for most people.
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These are the most common side effects seen in people with plaque psoriasis during the first 16 weeks of clinical trials:
These side effects occurred in between 1 percent and 14 percent of people, with most being mild to moderate.
Tremfya can cause serious side effects that need immediate medical attention. Serious allergic reactions, including anaphylaxis requiring hospitalization, have been reported.
Watch for rash, swelling of face or throat, trouble breathing, or dizziness. Tremfya may lower your ability to fight infections, so tell your doctor about any fever, flu-like symptoms, or infections that won’t go away.
Your doctor must test you for tuberculosis (TB) before starting treatment. Active TB has been reported in some people taking Tremfya.
Johnson & Johnson, the manufacturer of Tremfya, offers the Tremfaya withMe program. Eligible adults with commercial insurance may pay as little as $0 per injection.
The program includes dedicated nurse support, benefits verification, and help with prior authorization. Phone support is available in over 100 languages at 833-948-4631.
For those without insurance or who can’t afford treatment, the Johnson & Johnson Patient Assistance Program may provide Tremfya at no cost for up to one year based on income eligibility.
Before starting Tremfya, your doctor will test you for tuberculosis and ensure you’re up to date on vaccinations. Live vaccines should be avoided during treatment.
Tell your doctor about all medications and supplements you take, as some may interact with Tremfya. Also discuss any current infections or history of recurring infections, and let them know if you’ve been around someone with TB.
Tremfya is FDA-approved to treat people age 6 and up who have moderate to severe plaque psoriasis or active psoriatic arthritis, as well as adults with moderate to severe ulcerative colitis or Crohn’s disease. If you miss a dose, take it as soon as you remember and continue with your regular schedule.
There’s a pregnancy registry for people taking Tremfya during pregnancy. Discuss pregnancy plans with your doctor.
These answers are fact-checked by our editorial staff.
How effective is Tremfya for treating psoriasis plaques?
In clinical trials, many people saw improvement in their psoriasis symptoms after starting Tremfya. After 16 weeks, 7 out of 10 people had their psoriasis improve by at least 90 percent. Some people had completely clear skin. Everyone is different, so your results may vary. Talk to your doctor about what to expect.
How long does Tremfya take to work for psoriasis symptoms?
Tremfya was studied for plaque psoriasis with results measured at Week 16, when many people achieved clear or almost clear skin.
Does Tremfya cause weight gain in people with psoriasis?
Weight gain wasn’t reported as a side effect in clinical trials of Tremfya for psoriasis.
Is Tremfya more effective than adalimumab (Humira) for psoriasis?
Studies showed Tremfya had higher response rates than adalimumab at certain time points, but individual responses vary. Discuss with your doctor which medication is best for you.
On MyPsoriasisTeam, people share their experiences with psoriasis, get advice, and find support from others who understand.
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