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About MyPsoriasisTeam


Trexall is a prescription medication approved by the Food and Drug Administration (FDA) to treat severe psoriasis. Trexall is also known by its drug name, Methotrexate. Trexall may be prescribed along with biologic drugs such as Enbrel or Stelara, since they are more effective when taken together.

Trexall is an immunomodulator, or, in other words, a drug that modulates the immune system. Trexall is also referred to as a disease-modifying anti-rheumatic drug (DMARD) or a slow-acting anti-rheumatic drug (SAARD). Trexall is believed to work in cases of psoriasis by slowing the growth of cells.

How do I take it?
Trexall is taken once a week, either by injection or orally as a tablet.

Side effects
The side effects of Trexall may be worse among older adults, people who drink alcohol, and in those who receive higher doses of the drug.

The most commonly reported side effects of Trexall are mouth ulcers, malaise, fatigue, nausea, abdominal distress, changes in blood cell count, dizziness, abnormal liver function test results, and lowered resistance to infection.

Rarely, Trexall can cause liver damage and scarring when taken for long periods of time.

For answers to frequently asked questions about exposure to Methotrexate during pregnancy and breastfeeding, visit the experts at

Trexall (Methotrexate) for Psoriasis Questions

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