Trexall (Methotrexate) for Psoriasis | MyPsoriasisTeam

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Trexall is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat severe psoriasis. Trexall is also known by its drug name, methotrexate. Trexall may be prescribed along with biologic drugs such as Enbrel or Stelara.

Trexall is an immunomodulator, or, in other words, a drug that modulates the immune system. Trexall is also referred to as a disease-modifying anti-rheumatic drug (DMARD) or a slow-acting anti-rheumatic drug (SAARD). Trexall is believed to work in cases of psoriasis by slowing the growth of cells.

How do I take it?
Trexall is taken once a week, either by injection or orally as a tablet.

Side effects
The most commonly reported side effects of Trexall are mouth ulcers, malaise, fatigue, nausea, abdominal distress, changes in blood cell count, dizziness, abnormal liver function test results, and lowered resistance to infection. The side effects of Trexall may be worse among older adults, people who drink alcohol, and in those who receive higher doses of the drug.

Rarely, Trexall can cause bone marrow suppression, lung disease, lymphoma, diarrhea, skin reactions, and liver damage and scarring.

For more information about this treatment, visit:

Trexall — RxList

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