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TOPICAL CORTICOSTEROID/RETINOID
Wynzora (calcipotriene and betamethasone dipropionate) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) to treat plaque psoriasis in adults ages 18 and older.
Wynzora is a prescription topical treatment applied to the skin. It contains two medicines:
Wynzora changes skin cell activity and reduces inflammation, but the exact way it treats plaque psoriasis on the scalp and body is not fully known.
Doctors prescribe Wynzora when adults ages 18 and older have plaque psoriasis.
Wynzora is a cream that you apply to affected skin. Rub it in gently so the plaques are covered with the cream.
Do not use Wynzora on your face, groin, underarms, or areas where the skin is thinning. Do not use it in your mouth, eyes, or vagina.
Wash your hands after applying Wynzora.
Do not cover treated skin with a bandage or other tight covering unless your healthcare provider tells you to.
Use Wynzora exactly as directed by your healthcare provider.
The recommended dose of Wynzora for plaque psoriasis is to apply it to affected areas once daily for up to eight weeks. Your doctor may tell you to stop treatment when your psoriasis is under control.
Do not use more than 100 grams per week.
This information is based on prescribing information, but your healthcare provider may tailor your treatment plan. Always follow their guidance.
In a clinical study of adults with plaque psoriasis, the most common side effects occurred in about 1 percent to 7 percent of people and included:
Wynzora can cause serious side effects that may require immediate medical attention. These include:
Get medical help right away if you think you are having a serious reaction.
Mayne Pharma offers a Copay Savings Card for Wynzora. Eligible people with commercial insurance may pay as little as $0.
For more information, call 888-927-3499.
Tell your doctor if you are allergic to calcipotriene, betamethasone dipropionate, or any other ingredient in Wynzora.
Tell your doctor about all medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Be sure to mention other corticosteroid medicines and skin products containing corticosteroids or calcipotriene. Using more than one corticosteroid product may increase the risk of side effects.
Wynzora may increase the chance of having a baby with low birth weight. During pregnancy, use it on the smallest skin area and for the shortest time possible.
During breastfeeding, use Wynzora on the smallest skin area and for the shortest time possible. Do not apply it directly to the nipple or areola.
These answers are fact-checked by our editorial staff.
How effective is Wynzora for psoriasis?
In an 8-week study of adults with mild to moderate plaque psoriasis, 37.4 percent of people who used Wynzora once daily had skin rated “clear” or “almost clear” with at least a 2-grade improvement. This compared with 3.7 percent of people who used vehicle cream.
Among people who started with an itch score of 4 or higher, 60.3 percent had at least a 4-point improvement in itch by week 4. This compared with 21.4 percent of people who used vehicle cream. Results vary, and not everyone has the same response.
How long does Wynzora take to work for psoriasis?
In the clinical study, itch improvement was measured at week 4, and some people had meaningful improvement by that time. Skin-clearing results were measured at week 8.
The exact time it takes to work may vary from person to person.
Can Wynzora be used on the face or under a bandage for psoriasis?
Do not use Wynzora on your face, groin, or underarms. Do not cover treated skin with a bandage or other covering unless your healthcare provider tells you to.
Do not use Wynzora in your eyes, mouth, or vagina.
On MyPsoriasisTeam, people share their experiences with psoriasis, get advice, and find support from others who understand.
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