I have psoriatic arthritis affecting large and small joints, neck, back, but without actual psoriasis patches. I have put off starting a biologic due to concern with black box warnings that they can possibly cause cancer due to decreased immune function. My father had RA and was on Orencia. He developed lung cancer and of course they stopped the Orencia. Thoughts? Anyone else have this concern? I am very stiff and sore and wondering if I should start them.