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Real members of MyPsoriasisTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Asking if anyone has had good experiences with sulfasalazine & otezla combined?

A MyPsoriasisTeam Member asked a question 💭

I have plaque psoriasis on my
scalp, Elbow and feet and psoriatic arthritis that moves all over my body

October 13, 2024
 · 
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A MyPsoriasisTeam Member

This was my treatment for 9 months. I started with Otezla which cleared my plaque psoriasis completely; when my
Psoriatic arthritis worsened the sulfasalazine was added and titrated up to 6 pills a day. While i felt good, had plenty of energy I had to discontinue treatment due to GI issues ( reflux, nausea, constant diarrhea) Disappointed because I felt physically better but the side effects really impaired my quality of life. We are all different, I
sincerely hope this works well for you

January 29, 2025 (edited)
MyPsoriasisTeam

Combining sulfasalazine and Otezla (apremilast) for treating plaque psoriasis and psoriatic arthritis can be effective, but it's essential to follow your doctor's guidance. Here are some key points about each medication:

Sulfasalazine
- Usage: Taken orally in tablet form, usually with meals
- Common Side Effects: Reduced Show Full Answer

Combining sulfasalazine and Otezla (apremilast) for treating plaque psoriasis and psoriatic arthritis can be effective, but it's essential to follow your doctor's guidance. Here are some key points about each medication:

Sulfasalazine:
- Usage: Taken orally in tablet form, usually with meals.
- Common Side Effects: Reduced appetite, headache, nausea, vomiting, abdominal pain, and low sperm count.
- Serious Side Effects: Pain during urination, less-frequent or no urination, ringing in the ears, chest pain, blistering or peeling rash, flu symptoms, signs of liver problems.

Otezla:
- Usage: Taken orally as a tablet twice a day.
- Common Side Effects: Diarrhea, nausea, upper respiratory tract infection, headache.
- Serious Side Effects: Weight loss, nausea, vomiting, depression.

Considerations:
- Monitoring: Regular blood tests and liver function tests are recommended when taking sulfasalazine.
- Approval: Otezla is approved for all severity levels of plaque psoriasis and psoriatic arthritis.

Always consult your healthcare provider to tailor the treatment to your specific needs and monitor for any adverse effects.

October 13, 2024

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