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Real members of MyPsoriasisTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Anyone have intravenous infliximab and methotrexate for severe plaque scalp psorisis and PSA? Please share as I am to start this.

A MyPsoriasisTeam Member asked a question 💭
Pineville, LA
May 13, 2025
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A MyPsoriasisTeam Member

I was on Infliximab for about a year, but always had to be pretreated with prednisone, Tylenol and 100mg. Benadryl before my infusion. so my whole day was spent sleeping, Early on in my treatment/ diagnosis I was on Methotrexate for about 6 months with no side effects except for weightloss. So that was stopped.
I did develop a sensitivity to Remicade after about a year and switched to Simponi Aria, little effect in progression of damage. Now I am on Tremfya, seems to be holding most symptoms in check. Good luck in your journey, gentle hugs to you!☺️

May 14, 2025
A MyPsoriasisTeam Member

I can speak from experience be very aware that methotrexate can and often does affect your bone marrow to have low white blood cell count after or during. I had to take it because it was the only medication I tolerated at the time and now have trouble with my white count being in a normal range. Now I have to go to a specialist soon to deal with possible bone marrow damage from it. Be careful using that

May 14, 2025
MyPsoriasisTeam

Methotrexate is commonly used to treat moderate to severe psoriasis and can be administered either orally (as pills), through subcutaneous injection under the skin, or via IV infusion. It works by slowing down cell turnover and suppressing the immune system, which helps reduce psoriasis symptoms and inflammation.

For scalp Show Full Answer

Methotrexate is commonly used to treat moderate to severe psoriasis and can be administered either orally (as pills), through subcutaneous injection under the skin, or via IV infusion. It works by slowing down cell turnover and suppressing the immune system, which helps reduce psoriasis symptoms and inflammation.

For scalp psoriasis specifically, when other treatments haven't been effective, systemic medications like methotrexate may be prescribed. When taking methotrexate, you'll likely need to take folic acid supplements since the medication can deplete folic acid levels in your body. While methotrexate has been used since 1972 and can be effective, newer biologic treatments tend to have higher success rates. Methotrexate shows about 25-30% success rate compared to biologics which show 80-85% success rates. A MyPsoriasisTeam member shared that their psoriasis calmed down and their body pain improved while on methotrexate, though they noted the effectiveness decreased over time.

May 13, 2025

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