When should methotrexate be taken during the day?
Methotrexate for psoriasis is typically taken once weekly, but the search results don't specify a particular time of day that's best. The timing is less important than consistency and following your doctor's specific instructions.
Some people find it helpful to take Show Full Answer
When should methotrexate be taken during the day?
Methotrexate for psoriasis is typically taken once weekly, but the search results don't specify a particular time of day that's best. The timing is less important than consistency and following your doctor's specific instructions.
Some people find it helpful to take methotrexate at a time when they can rest afterward, especially if they experience side effects like fatigue or nausea. Taking it in the evening might allow you to sleep through some of these effects.
If nausea is an issue, splitting the weekly dose into three smaller doses taken 12 hours apart can sometimes help reduce this side effect.
The most important thing is to take it on the same day each week and follow your doctor's guidance about timing, especially regarding food and any other medications you're taking.
October 31, 2025