Is there a safe medication for psoriatic arthritis and skin psoriasis if you don't have a spleen?
Not having a spleen puts you at higher risk for infections, which is an important consideration when choosing treatments. Many psoriatic arthritis medications affect the immune system, which could further increase infection Show Full Answer
Is there a safe medication for psoriatic arthritis and skin psoriasis if you don't have a spleen?
Not having a spleen puts you at higher risk for infections, which is an important consideration when choosing treatments. Many psoriatic arthritis medications affect the immune system, which could further increase infection risk.
Several treatment options may be considered, but each requires careful discussion with your doctor:
* NSAIDs (like ibuprofen or naproxen) for mild to moderate symptoms - these don't suppress the immune system as much
* Corticosteroid injections for specific joint pain - used short-term rather than as ongoing treatment
* DMARDs like methotrexate - though these do affect immune function
* Biologics - these target specific parts of the immune system and can treat both joint and skin symptoms
* JAK inhibitors or PDE4 inhibitors - newer oral medication options
The key is working closely with both your rheumatologist and primary care doctor. They'll need to weigh the benefits of controlling your psoriatic arthritis and psoriasis against your increased infection risk without a spleen.
Your doctor may recommend additional precautions like staying current on vaccinations and monitoring closely for any signs of infection while on treatment.
November 20, 2025
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