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Real members of MyPsoriasisTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
December 20, 2025
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MyPsoriasisTeam

Are you experiencing extreme fatigue about 3 days after taking Tremfya?

While Tremfya (guselkumab) has shown good results for many people with psoriasis and psoriatic arthritis, everyone responds differently to medications. The extreme tiredness you're describing isn't listed among the commonly reported side effects, but Show Full Answer

Are you experiencing extreme fatigue about 3 days after taking Tremfya?

While Tremfya (guselkumab) has shown good results for many people with psoriasis and psoriatic arthritis, everyone responds differently to medications. The extreme tiredness you're describing isn't listed among the commonly reported side effects, but that doesn't mean it's not affecting you personally.

It's really important to talk to your doctor about this fatigue pattern you're experiencing. They can help determine if:

* This is a side effect specific to how your body processes the medication
* The timing is coincidental with other factors
* Your treatment plan needs adjustment

Keep track of when these crashes happen and any other symptoms you notice. This information will be valuable for your healthcare team in figuring out what's going on and whether Tremfya is the right treatment for you.

Don't hesitate to reach out to your doctor sooner rather than later, especially if this fatigue is significantly impacting your daily life.

December 20, 2025

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