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Real members of MyPsoriasisTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A MyPsoriasisTeam Member asked a question 💭
Delray Beach, FL

I am not receiving the positive results of a years ago. Contemplating upgrading dosage to 180mg. Skyrizi has worked very well for my Psoriasis, and moderately for PSa. I have been thru too many other medications to start trying again. I also have Spondylitis, which adds to the pain. I am 67, and wonder if some of these aches & pains are normal for my age? Has anyone been in a similar situation?

January 27
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A MyPsoriasisTeam Member

Donna if you like , I hope you do get the chance to SPEAK & ASK QUESTIONS,& i am not Angry, just making a Important Point to my new friend Donna, 😉 when you next visit your Doctors. Maybe you would be able to Open & give something Different to your Doctor to Think 🤔 about. Everyone needs to Speak Up if they are in pain, not seeung improvement , remind to look at ALL the effects, not just skin. . Best of EVERYTHING

January 30
A MyPsoriasisTeam Member

Donna, hello, I am Terri, I was on the STUDY FOR SKYRIZI, for six years, started in 2019, ended the study in 2025. Tho they treated the 1st 2years with that Drug, Skyrizi, it worked , the same way, like what you are going thru. Good for awhile , excellent on my akin,Ps, but not so on my joint. I was in terrible pain. They took me off the study drug ( Skyrizi)BUT wanted me to remain being followed
On The Study. I SAID YES,SIR. I was placed on a number of Biologic, on fir a good amount of time, then removed me, so again, another 4 times more new drugs, neverr works well,not on pain but my skin , that was good, but I need something that would work For Me, the whole shebang. What Not Me! After 4 years, I was looked at by another doctor in the practice, she did different test and SHE determined that not only did I have PsA & Pa, my tests cane back with my new friend, RA. I think Kellie you should speak up , ask him or her,to check you out for RA. See what happens & I believe all the time. A person walks in a office with joint pain and your skin has PLAQUES, THEY S.T.O.P. Because your SKIN IS INFRAMED, ok thats easy, Differently PSORIASIS SO THEREFORE PsA, not the case., not My Case. You have to be your Own Advocate. Stand up and let them hear you, have them listen. Doctor's can be stuck on the first thing they see ( your Skin),& automatically say PsA,diagnosed & without thinking it maybe more than that . Its your job now.i really would be SURPRISE if your case, isn't exactly like My CASE. Took 45 year to DIAGNOSIS ME with the RIGHT, CORRECT DIAGNOSIS Praise the Lord . I am wishing you a Brand New GOOD Year ahead terri

January 27
A MyPsoriasisTeam Member

Every medication stops to works, because your body get use to it. The best thing it's to get adding mls until you get the highest dose available. Sometimes the drs prefer to change the medications until you get the right one.

February 4
MyPsoriasisTeam

Has Skyrizi become less effective after two years, and should you consider increasing the dosage?

It's not uncommon for some psoriatic arthritis medications to become less effective over time. This is something worth discussing with your rheumatologist, as they can evaluate whether adjusting your dosage or exploring other Show Full Answer

Has Skyrizi become less effective after two years, and should you consider increasing the dosage?

It's not uncommon for some psoriatic arthritis medications to become less effective over time. This is something worth discussing with your rheumatologist, as they can evaluate whether adjusting your dosage or exploring other options might help.

Before making any changes, it's important to have a conversation with your doctor about:
- Whether increasing the dosage is appropriate for your situation
- What side effects to expect and how they might differ at a higher dose
- How long you should try the new dosage before deciding if it's working
- Whether the reduced effectiveness is related to the medication or other factors

Your doctor can help determine if the medication is truly losing effectiveness or if other factors, like disease progression or the spondylitis, are contributing to your symptoms. Regarding your concerns about age-related pain:

It can be challenging to distinguish between psoriatic arthritis symptoms, spondylitis pain, and age-related aches. Spondylitis causes inflammation of the spine, leading to neck and lower back pain, which can significantly add to your discomfort.

A MyPsoriasisTeam member shared a similar experience, noting that biologics and methotrexate help but don't completely eliminate pain and stiffness. They emphasized that managing both psoriasis and psoriatic arthritis can be difficult, especially when trying to stay active with grandchildren.

The combination of psoriatic arthritis and spondylitis can make it particularly hard to determine what's causing specific symptoms. Your rheumatologist can help assess whether your current pain levels are adequately controlled or if adjustments to your treatment plan are needed.

January 27

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A MyPsoriasisTeam Member asked a question 💭
Vancouver, BC