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Real members of MyPsoriasisTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A MyPsoriasisTeam Member asked a question 💭
North Branch, MN
August 10
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A MyPsoriasisTeam Member

Ok, probably not then, as I was told I can’t compromise my immune system, as it could cause that to flare up again.

August 10
MyPsoriasisTeam

That's a really important question to bring up with your dermatologist or rheumatologist before starting any interleukin (IL) inhibitor treatment.

Interleukin inhibitors work by targeting specific immune signals that drive psoriasis. Because they affect the immune system, they can increase the risk of certain infections — Show Full Answer

That's a really important question to bring up with your dermatologist or rheumatologist before starting any interleukin (IL) inhibitor treatment.

Interleukin inhibitors work by targeting specific immune signals that drive psoriasis. Because they affect the immune system, they can increase the risk of certain infections — including fungal infections, which is the category that valley fever falls into. A few things worth knowing before your appointment:

- IL-17 inhibitors in particular can raise the risk of fungal infections, since IL-17 normally helps the body defend against them
- IL-23 inhibitors are considered more targeted and don't suppress the immune system as broadly, which may make them a different consideration
- Doctors typically screen for infections before starting these treatments and monitor patients regularly throughout

Having a history of valley fever doesn't automatically rule out interleukin treatment, but your doctor needs to know about it. They'll weigh your history carefully and may consult with an infectious disease specialist before making a recommendation.

Be upfront about your valley fever history — it's exactly the kind of detail that helps your care team choose the safest and most effective treatment for you.

August 10

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