Great questions! Let's tackle both of these.
Icotyde (icotrokinra) is a newer once-daily pill approved by the FDA in March 2026 for moderate to severe plaque psoriasis in adults and teens 12 and up. It works by blocking the IL-23 receptor, which drives inflammation in psoriasis.
The clinical trial results are pretty Show Full Answer
Great questions! Let's tackle both of these.
Icotyde (icotrokinra) is a newer once-daily pill approved by the FDA in March 2026 for moderate to severe plaque psoriasis in adults and teens 12 and up. It works by blocking the IL-23 receptor, which drives inflammation in psoriasis.
The clinical trial results are pretty encouraging:
- Around 70% of people reached "clear" or "almost clear" skin by Week 16
- About 74% achieved complete or near-complete skin clearance overall
- Nearly half reached complete skin clearance by Week 52
- Rare but serious risks include infections
It's worth talking to a dermatologist about whether it could be a good fit, especially if injections haven't been ideal. As for fatigue — it's a real and common part of living with psoriasis. Some psoriasis medications, including immune-modifying treatments, can also contribute to tiredness.
Here are some strategies that may help:
- Talk to your doctor — if a medication is causing fatigue, adjusting the dose or switching treatments may help
- Start light exercise — even a 15-minute walk can boost energy levels
- Eat well — lean proteins, whole grains, fruits, and veggies with anti-inflammatory properties (like salmon, leafy greens, and olive oil) can make a difference
- Ask about supplements — Vitamin D, B vitamins, and omega-3 fish oil have helped some people
- Rest intentionally — spread out chores and build in planned breaks
- Keep a fatigue diary — tracking sleep, food, activity, and flares can help spot patterns
One MyPsoriasisTeam member shared: "When I'm fatigued, I try to keep my daily routine but just go through the motions and get the basics done."
Always check with a doctor before making changes to diet, exercise, or supplements.
September 2
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