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The flares involve both my psoriasis and my PsA. The infusion nurse said it’s common for any infusion drug. I’ve learned to not plan anything for the week before infusion because it’s just too painful. I’m also on methotrexate to decrease the chance of becoming immune to Remicade. I would appreciate suggestions on how to cope.

October 17
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MyPsoriasisTeam

What are some ways to cope when Remicade seems to wear off before the next infusion cycle?

This is a really common experience, and it's frustrating to lose a whole week every cycle to a flare. The good news is that others have navigated this and found ways to manage it.

The most important first step is to talk openly with Show Full Answer

What are some ways to cope when Remicade seems to wear off before the next infusion cycle?

This is a really common experience, and it's frustrating to lose a whole week every cycle to a flare. The good news is that others have navigated this and found ways to manage it.

The most important first step is to talk openly with your doctor or rheumatologist about what's happening. There are a few things they might consider:

- Adjusting the infusion interval — some people move from every 8 weeks to every 6 or 7 weeks
- Reviewing your overall treatment plan to see if any short-term relief options can help bridge that difficult final week
- Monitoring whether the wearing-off gets worse over time, which can be a sign worth tracking and reporting Other MyPsoriasisTeam members have shared practical tips that help them get through infusion cycles:

- Track your symptoms week by week after each infusion — this gives your doctor useful data and helps you anticipate the harder days
- Stay well hydrated in the days leading up to infusion day, as some members find this helps the process go more smoothly
- Plan lighter activities during your difficult week, which it sounds like you're already doing — that's genuinely smart self-management
- Communicate early with your care team if the wearing-off effect seems to be getting worse or starting sooner each cycle

One MyPsoriasisTeam member shared: *"By the fourth week after the infusion my symptoms begin to return with increased joint and muscle pain along with fatigue"* — so you're definitely not alone in this experience.

Being proactive with your doctor rather than just enduring that final week is really the key. You shouldn't have to write off a whole week every two months if there are options to improve things.

October 17

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Roanoke, VA