Palmoplantar pustulosis is a rare, chronic skin condition that causes recurring pustules on the palms of the hands and soles of the feet, and is often considered a form of psoriasis.
PPP can cause itching, pain, thick scaling, and cracked skin that makes everyday activities like walking or holding objects very difficult. Researchers are still learning about what causes PPP, but possible factors include sweat gland disorders, genetic changes, and certain triggers like smoking or infections.
If you think you might have palmoplantar pustulosis, reaching out to a dermatologist is a great first step, as they can help you find a treatment plan that works for your symptoms and overall health.
If you’ve had breakouts of itchy, scaly, or painful pustules on the soles of your feet or the palms of your hands, you may have palmoplantar pustulosis (PPP).
Palmoplantar pustulosis is often considered a form of psoriasis. Up to 24 percent of people with PPP also have psoriasis on another part of the body. Other names for the condition include chronic palmoplantar pustular psoriasis and pustulosis palmoplantaris.
If you have palmoplantar pustulosis — or think you might — talk with your dermatologist. Although this condition can sometimes be challenging to manage, there are treatments that may help.
🗳️ How much do palmoplantar pustulosis symptoms affect your day-to-day life?
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Read on to learn more about palmoplantar pustulosis and how it may affect people with psoriasis, including people with psoriasis on the hands or feet.
What Is Palmoplantar Pustulosis?
Palmoplantar pustulosis is a rare, chronic skin condition that can come and go over time and causes recurring sterile pustules on the palms and soles. The pustules aren’t contagious or caused by germs. PPP can cause itching, pain, thick scaling, cracked skin, and trouble using the hands or feet.
Recognizing Palmoplantar Pustulosis Symptoms
Palmoplantar pustulosis is sometimes classified as a localized form of pustular psoriasis, although some health experts consider it a separate condition. It specifically affects the palms of the hands and soles of the feet, unlike generalized pustular psoriasis, which can show up anywhere on the body.
PPP symptoms that may develop on your palms and soles include:
Thick plaques (patches of thick, discolored skin that may resemble plaque psoriasis)
Itching
Pain or a burning sensation
Scaly skin that may turn brown or yellow, depending on your skin tone
Fissuring (cracked skin)
Palmoplantar pustulosis can resemble other skin disorders, which may make it difficult to diagnose. These conditions include acrodermatitis continua of Hallopeau, a related skin disease, and the following skin disorders:
Contact dermatitis
Dyshidrotic eczema
Pityriasis rubra pilaris
Palmoplantar keratoderma
Pictures of Palmoplantar Pustulosis Symptoms
Palmoplantar pustulosis can significantly affect your quality of life. The painful cracks and lesions can make daily activities such as walking, standing, and using your hands difficult.
PPP symptoms may be worsened by weather changes, pressure or friction, manual labor, or household chores that involve detergents or other irritants.
Palmoplantar pustulosis can cause severe pustules and peeling on the palms, making it hard to perform daily activities that require the use of your hands. (CC BY-NC-ND 4.0/DermNet)
When palmoplantar pustulosis develops on the soles of the feet, walking can become painful and difficult. (CC BY-NC-ND 4.0/DermNet)
Although palmoplantar pustulosis refers to a condition on the palms or soles, other areas of the body, particularly the nails, may also be affected.
Toenails and fingernails may also be affected by palmoplantar pustulosis. (CC BY-NC-ND 4.0/DermNet)
MyPsoriasisTeam Members on Palmoplantar Pustulosis
PPP flare-ups can greatly affect your life. MyPsoriasisTeam members living with palmoplantar pustulosis have shared their experiences and frustrations.
“I have palmoplantar pustulosis psoriasis — trying to learn everything I can. So far, trying diet changes, stress control, natural remedies, and moisturizer creams,” a member wrote. “I have one flare-up after another. The prospect of this spreading and getting worse isn’t comforting.”
Another member said, “I have palmoplantar psoriasis and am in a huge flare. I can barely hold a cup! It makes everything seem 100 times harder. I guess the only good thing is no dishes.”
One MyPsoriasisTeam member wrote, “I also have palmoplantar psoriasis, and mine has spread fairly rapidly. I have also noticed two small patches on my arm. My family doctor thought it was psoriasis coming in there also. The new ones on my arm don’t look like much yet, so I’m not sure what is going to happen.”
What Causes Palmoplantar Pustulosis?
Palmoplantar pustulosis is an autoinflammatory condition, but medical researchers don’t fully understand its cause.
Researchers have several theories about factors that may be linked to PPP, including:
Disorders in the eccrine sweat glands, which are prevalent in hands and feet
Genetic variants or mutations (changes)
Bacterial infections such as chronic sinusitis, chronic or acute tonsillitis, and dental infections
Contact allergic reaction to some metals
Sinusitis, tonsillitis, dental infections, and metal sensitivity are best understood as possible triggers or associated factors, not proven direct causes. Some dermatology research also describes drug-induced paradoxical PPP, or PPP in response to a drug, as a special form of the condition.
Tumor necrosis factor (TNF)-alpha inhibitors are biologic medications used to treat psoriasis and other inflammatory conditions. In rare cases, they may be linked to paradoxical PPP, meaning the medication may trigger a condition it might otherwise be expected to help.
Risk Factors
Women are more likely than men to develop palmoplantar pustulosis, according to the National Psoriasis Foundation. A family history of psoriasis is also found in some people with palmoplantar pustulosis.
Smoking or having smoked in the past is also a recognized risk factor for PPP. Smoking is associated with inflammation and vascular damage (affecting the blood vessels) in the skin.
What Comorbidities Are Linked to Palmoplantar Pustulosis?
People with palmoplantar pustulosis have a risk of developing some of the same comorbidities (coinciding conditions) that occur in people with psoriasis. These include heart disease, metabolic disorders, and psychiatric conditions.
Compared with people with psoriasis, people with PPP may have a higher risk of developing conditions such as type 1 or type 2 diabetes, allergic contact dermatitis, celiac disease, and inflammatory bowel disease.
People with palmoplantar pustulosis may be less likely than people with psoriasis to develop other comorbidities, such as:
Some comorbidities may be serious if left untreated, so be sure to discuss your risks with your doctor.
How Is Palmoplantar Pustulosis Treated?
Palmoplantar pustulosis can sometimes be challenging to manage, but several topical and systemic treatment options, as well as light therapy, may help control symptoms.
There are no U.S. Food and Drug Administration (FDA)-approved treatments specifically for PPP. Some treatments overlap with psoriasis treatments, but your dermatologist will recommend therapies based on your symptoms, overall health, and treatment history.
Always discuss a new treatment in detail so that you understand exactly how it should be used and are aware of any potential side effects.
Topical Treatments
Topical therapies that may be used first include corticosteroids, sometimes with occlusion — covering to increase effectiveness — and calcipotriene cream (Dovonex). Other over-the-counter (OTC) and prescription emollients, ointments, or creams with ingredients such as coal tar, salicylic acid, and urea may help some people.
Always discuss OTC products with your dermatologist before trying them, because some ingredients can make medications less effective. For instance, salicylic acid should not be used with calcipotriene. Topical steroids should be used only as directed to avoid unwanted side effects.
Oral Treatments
Systemic oral medications may include:
Acitretin, an oral retinoid derived from vitamin A
Methotrexate, a disease-modifying antirheumatic drug (DMARD)
Cyclosporine, an immunosuppressant
Apremilast (Otezla), a phosphodiesterase 4 inhibitor that has been studied for PPP
Acitretin must not be used during pregnancy, and pregnancy must be avoided during treatment and for three years after taking it.
Apremilast is not FDA-approved specifically for PPP. A recent review reported that apremilast showed better response rates than placebo in a clinical trial, but evidence is still limited.
Light Therapy
Newer treatments with laser therapy have been reported as promising. Standard light therapies — also known as phototherapy — for palmoplantar pustulosis include psoralen with ultraviolet A light (PUVA) and narrowband ultraviolet B.
“I have just completed PUVA treatment for my palmoplantar pustular psoriasis,” one MyPsoriasisTeam member reported. “I would say it’s 90 percent gone. I had 32 treatments over almost five months.”
Biologics
In severe cases in which palmoplantar pustulosis doesn’t respond to other treatment options, a specialist may recommend biologics. These drugs are administered by either subcutaneous (under the skin) injection or intravenous infusion. Their use for PPP is generally off-label in the United States.
If you also have palmoplantar psoriasis symptoms on your feet, your doctor may adjust your treatment plan based on where symptoms appear and how much they affect your daily activities.
Skin Care Tips
Along with sticking to your recommended treatment plan, focusing on skin care can help protect irritated skin. Avoid harsh soaps, bubble bath, or shower gel on affected areas.
Instead, use a fragrance-free emollient or moisturizing cleanser, especially if your skin is cracked. Moisturize affected areas regularly.
Identifying and avoiding triggers can also help protect skin from outbreaks of palmoplantar pustulosis.
MyPsoriasisTeam Members on Managing Palmoplantar Pustulosis Symptoms
MyPsoriasisTeam members have shared personal tips for skin care that have helped relieve their PPP symptoms. These are personal experiences, not proven PPP treatments. Talk with your dermatologist before trying a home remedy.
“Cotton socks and Hydromol on for bed — I have pustular palmoplantar psoriasis on my soles and palms,” said one member. “It will help to reduce cracking.”
Another member offered this tip: “I have been using aloe vera from my homegrown plant! I peel one side of the aloe cut from the plant, trim, and place the peeled (sharp bits removed) and juicy side of the leaf on the affected arch of my foot and hold it in place with a bandage. Socks on, shoes on, and off to work. I keep this in place all day. The healing at the end of the day is unbelievable. I do the same at night on my affected hands.”
Stay in Contact With Your Dermatologist
Maintaining good communication with your dermatologist is essential for your care. If you have palmoplantar pustulosis, let your doctor know about any new, changing, or worsening symptoms. Effective management of PPP symptoms and disease activity may help you avoid complications and feel your best.
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The backs of my ankles and lower leg get these pustules. Burning pain
Jagged nerve pain. Haven:,t had a flare in a couple of years. Using
Salicydic acid cream. Going to try
..my light therapy on it.… read more
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Terms of Use, and
acknowledge our collection, sharing, and use of your data in accordance with our
Health Data and
Privacy policies.
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The backs of my ankles and lower leg get these pustules. Burning pain
Jagged nerve pain. Haven:,t had a flare in a couple of years. Using
Salicydic acid cream. Going to try
..my light therapy on it.… read more
We'd love to hear from you! Please share your name and email to post and read comments.
You'll also get the latest articles directly to your inbox.