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Real members of MyPsoriasisTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
January 27, 2024
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A MyPsoriasisTeam Member

Have not have taken what you mention above

January 28, 2024
A MyPsoriasisTeam Member

I had Methotrexate added to my Taltz when it stopped working as well - it helped but then I started loosing my hair - lost about half my volume so I stopped that as I could not deal with the amount of hair I lost. Now on Tremfya - still early but seems to be working. I also recently started a 12 week Fix - first step was removing added sugar and processed foods. Seems to have really helped. But you have to remember that everyone has different reactions to drugs and you may not have the same ones. You need to listen to your own body and how it reacts. Many of the things I have been on have an initial reaction that tends to subside at about 2 weeks for me. Good luck finding what works for you.

January 28, 2024
MyPsoriasisTeam

Methotrexate is a medication commonly used to treat psoriasis and psoriatic arthritis (PsA). Here are some pros and cons based on the knowledge base:

Pros
- Effectiveness: Methotrexate can help calm down psoriasis and reduce joint pain associated with PsA.
- Convenience: It is usually taken once weekly, either orally or Show Full Answer

Methotrexate is a medication commonly used to treat psoriasis and psoriatic arthritis (PsA). Here are some pros and cons based on the knowledge base:

Pros:
- Effectiveness: Methotrexate can help calm down psoriasis and reduce joint pain associated with PsA.
- Convenience: It is usually taken once weekly, either orally or by injection, which can be done at home.
- Long History: It has been used since 1972 for treating psoriasis and PsA.

Cons:
- Side Effects: Common side effects include fatigue, nausea, vomiting, diarrhea, headaches, mild hair loss, and bone marrow suppression.
- Serious Risks: Long-term use can lead to kidney and liver dysfunction, and there is an increased risk of serious conditions like lymphoma, melanoma, and lung cancer.
- Supplementation: Folic acid supplements are often required.
- Effectiveness Compared to Biologics: Methotrexate is less effective than biologic therapies, with a success rate of 25-30% compared to 80-85% for biologics.
- Routine Monitoring: Regular blood tests are needed to monitor kidney and liver function.

If you experience severe side effects, it may be time to discuss alternative treatments with your doctor.

July 25, 2024
A MyPsoriasisTeam Member

Thank you for sharing your experience with me. I am altering my diet a little at a time and can already tell the difference in how I feel. The pain in my joints isn't as bad, but the inflammation hasn't subsided.

February 17, 2024

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