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I'm also on hydroxychloroquine, Cymbalta, and Celebrex. I'm thinking of adding Low Dose Naltrexone for pain relief. Has anyone tried it? My rheumatologist suggested Orencia infusions next. I'm leaning towards staying on Rinvoq along with LDN for a bit before switching to another medication. I have dactylitis in my left foot and toes and the swelling and stiffness will not go down. It's been like this for 9 months. My right toes are starting to get stiff as well. Any thoughts on Orenciaread more

June 24, 2025
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MyPsoriasisTeam

For dactylitis (swollen digits), steroid injections directly into the affected areas can provide quick relief from inflammation and discomfort. This might be worth discussing with your doctor as a targeted approach alongside your current treatment. Regarding Rinvoq, it's a newer JAK inhibitor that has shown promise for Show Full Answer

For dactylitis (swollen digits), steroid injections directly into the affected areas can provide quick relief from inflammation and discomfort. This might be worth discussing with your doctor as a targeted approach alongside your current treatment. Regarding Rinvoq, it's a newer JAK inhibitor that has shown promise for psoriatic arthritis when other treatments haven't worked. However, it's important to be aware of potential risks, including:

- Cardiovascular complications (stroke, heart attack)
- Increased risk of blood clots
- Possible increased risk of certain cancers
- Reduced ability to fight infections

Since you're experiencing some benefit but not complete relief, work closely with your rheumatologist to weigh these risks against the benefits you're receiving. Many MyPsoriasisTeam members have tried multiple medications before finding the right combination. While some have found success with Orencia after trying other biologics, treatment response varies significantly between individuals. Consider keeping a symptom diary to track your response to any medication changes, which can help inform future treatment decisions.

June 24, 2025

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