Has anyone had good results treating psoriasis with Skyrizi after other biologics failed?
Yes, some people have found success with Skyrizi even after other treatments didn't work well. One MyPsoriasisTeam member had nearly 100% of her body covered in severe plaques in 2017. After avoiding biologics for years and trying Show Full Answer
Has anyone had good results treating psoriasis with Skyrizi after other biologics failed?
Yes, some people have found success with Skyrizi even after other treatments didn't work well. One MyPsoriasisTeam member had nearly 100% of her body covered in severe plaques in 2017. After avoiding biologics for years and trying various topical treatments, she started Skyrizi when her condition worsened significantly.
Her results were encouraging:
- Itching stopped within two weeks
- Plaques began healing after two weeks
- Skin looked and felt better after six weeks
- Hair grew back and skin was clear after six months
Another member shared their experience trying multiple treatments before finding success. Their dermatologist created a comprehensive plan that eventually included biologics after other options like phototherapy, Cyclosporine, and Prednisone were tried.
It's worth noting that Skyrizi was approved by the FDA in 2019 for moderate to severe plaque psoriasis. It works differently than some other biologics by targeting a specific protein called IL-23 that causes inflammation.
Since you've tried two biologics already, talking with your dermatologist about what specifically didn't work with those treatments could help determine if Skyrizi might be a good fit for you. Everyone responds differently to treatments, so what works for one person may not work for another.
December 7, 2025
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