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Real members of MyPsoriasisTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Specifically how long do people feel they've taken something and then feel like it's not having an effect after a while? If you feel like putting the medicine and how long you could take it that's great but not needed to know what it is, just how long it seemed to only work for. Just want to compare if there's a certain time frame for many people doing that.

December 30, 2025 (edited)
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Answer Summary

Members shared widely varied experiences in response to a question about how long medications remain effective before losing their impact,... Read more

Members shared widely varied experiences in response to a question about how long medications remain effective before losing their impact, with timelines ranging from a few months to over eight years depending on the individual and the specific treatment. Several members described transitions between medications like Skyrizi, Xeljanz, Tremfya, and methotrexate, noting that some biologics helped skin symptoms but not joint pain, while others provided relief for one to two years on average before requiring a switch. A recurring theme was the deeply personal nature of medication response, with members emphasizing the importance of monitoring symptoms, staying proactive with doctors, and recognizing that what works for one person may not work for another.

A MyPsoriasisTeam Member

From what I've read from people here. Once it starts to work it last about two years on average. I've also read where people were great after 8 years. Still taking the same medication. Its different for everyone.

December 31, 2025
A MyPsoriasisTeam Member

I just read about the MTHFR gene and how people with that gene can't process folic acid. The buildup causes serious issues. You have to use natural folate. Folic acid is synthetic. I hope this helps..

January 8
A MyPsoriasisTeam Member

Iam on ilumya and so far so good it's getting rid of my nasty severe psoriasis. I have a very severe case on my palms, scalp, feet and legs so bad I can't walk. But since starting the ilumya I can walk and not feeling so exhausted anymore 😊!!!

January 20
A MyPsoriasisTeam Member

@A MyPsoriasisTeam Member below are the 2 vitamin I was talking about in my last post.

January 9
A MyPsoriasisTeam Member

@A MyPsoriasisTeam Member I too have MTHFR....in which I am at high risk for blood clots...I take a 81mg aspirin a day and was using lmethalfolate supplement my husband found these 2 vitamins that actually have more pre and probiotics, folate, etc.....Methylated Multivitamin Bioactive Forms Advanced Formula 2xs a day &
Super Enzymes+ 20 enzymes 200mg prebiotics 2 billion CFU probiotics advanced digestive formula 2xs a day.

If you have the blood clotting type and taking extra hormones you need to stop the hormones since any type of hormone (cream, patch, injection, etc.) Can cause blood clotting.

Hope this helps oh yeah my daughter and 2 of my grandsons also have the MTHFR gene but not the high risk for blood clots....their doctor has them on L-Methylfolate I believe....perscribed by their medication part of their therapy...the 14 year old is also has autism and adhd, the 13 year old is adhd and the 4 year old has signs of adhd and autism he has started play therapy and speech therapy which the 14 year old at around 2 we found out he could not hear us...turns out he needed tubes...after words he became very sensitive to noise and needed speech therapy....and again at 4 he and the now 13 year old then 2 had tubes and adnoid surgery.

January 9

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