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Did anyone here recently change their biologic treatment for psoriasis or psoriatic arthritis?

MyPsoriasisTeam asked a question 💭
San Francisco, CA

Members have shared different experiences with options including Bimzelx, Cosentyx, Skyrizi, and Taltz, etc. What have you tried, and what has the experience been like for you?

October 3, 2025
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Answer Summary

Members shared a wide range of experiences switching biologics for psoriasis and psoriatic arthritis, with popular choices including Tremfya,... Read more

Members shared a wide range of experiences switching biologics for psoriasis and psoriatic arthritis, with popular choices including Tremfya, Skyrizi, Cosentyx, Humira, and Taltz, though results varied greatly from person to person. Several members emphasized that finding the right biologic often takes time and trial, with some experiencing dramatic improvements (like complete clearing or significant pain relief) while others saw limited results, faced side effects like infections or hair loss, or struggled with high costs and insurance coverage changes. A recurring theme was the importance of patience, self-advocacy with doctors and insurance companies, exploring manufacturer assistance programs to reduce costs, and considering complementary approaches like diet changes, gut health support, light therapy, and natural treatments when biologics alone weren't enough.

A MyPsoriasisTeam Member

I started using Tremfya once.  When it was time to reorder Bio Plus wanted me to pay $1500.00.  I switched over to Skyrizi and there was no charge.  Love Skyrizi as it is doing a better job than Tremfya.

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October 6, 2025
A MyPsoriasisTeam Member

I have pustular psoriasis, one of the most severe forms, and I completely stopped biological treatments because I noticed that instead of controlling it properly, it caused a lot of changes in my immune system, and the lesions kept coming back every time I missed a treatment. It caused side effects such as a runny nose, constant burning in my eyes, loss of sleep, and worst of all, I never fully recovered. What I did was take a natural alternative. I follow an anti-inflammatory diet, drink natural herbal tea, and also took a natural medicine for leaky gut. If anyone reads this, look into it. An important tip is that if you don't sleep well, your body doesn't renew itself. Right now, I take melatonin and sleep fantastically, and I think I'm better off than I ever was with biological treatments. Take care of your organs if you continue with biological treatments, and get regular checkups. If anyone has any questions, I'm happy to answer them. I hope we can all live in peace with this diseas
e.

October 3, 2025
A MyPsoriasisTeam Member

I have had 3 different treatments. The fist 2 worked great for about 2 years each but then stopped being so effective. I was on Otezla, mild stomach upset for the first week but then nothing, then Tremfya with no side effects and when it stopped working so well added Methotrexate to that but that made my hair fall out. Now on Tremfya with no real side effects and still working for me after 2 years. Everyone reacts differently so work with your Dr and know there are alternatives if one doesn’t work or has too many side effects for you. Good luck!

October 7, 2025
A MyPsoriasisTeam Member

I have been on Humira for nine months (twice a month). I had to take a break from it due to extensive back surgery. Resuming again and not so sure it has been working. I also was taking Methotrexate. Stopped for surgery and don't want to take again because all of my hair was falling out.

October 3, 2025
A MyPsoriasisTeam Member

I just switched from Rinvoq to consentyx. I’m so happy! All my pain and fatigue is gone. I haven’t felt this good in 6 years. Strongly encourage anyone whose med is not doing a good job to try another. It was not a good month coming off Rinvoq and waiting for cosentyx to kick in. Kinda forgot what full blown disease felt like but it was so worth it. My rheumatologist did give me a steroid shot to get through the worst of it and I am just so happy to have my disease under control now

October 3, 2025

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