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Real members of MyPsoriasisTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
June 30
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MyPsoriasisTeam

That's a really valid question, and it's worth exploring. Taltz (ixekizumab) is a biologic used to treat psoriatic arthritis, and some biologics have been linked to weight gain, which could potentially be working against the weight loss effects of Zepbound (tirzepatide). There are also other factors related to psoriatic Show Full Answer

That's a really valid question, and it's worth exploring. Taltz (ixekizumab) is a biologic used to treat psoriatic arthritis, and some biologics have been linked to weight gain, which could potentially be working against the weight loss effects of Zepbound (tirzepatide). There are also other factors related to psoriatic arthritis itself that can make weight loss harder, including:

- Inflammation – Chronic inflammation associated with PsA is linked to excess body fat
- Joint pain and stiffness – This can limit physical activity, making it harder to burn calories
- Fatigue – Low energy levels can reduce motivation to exercise or cook healthy meals

As a MyPsoriasisTeam member once said, "Losing your mobility sucks! It's depressing! Debilitating, frustrating, sad. Not good for weight loss!" Interestingly, there is some early research suggesting that combining Taltz with Zepbound may actually lead to *greater* disease control in people with PsA who are overweight, compared to Taltz alone. So the combination isn't necessarily a bad thing.

It's best to bring this concern up with your doctor, who can review whether your current doses or treatment plan need adjusting to better support your weight loss goals.

June 30
A MyPsoriasisTeam Member

I am on Tremfya and Zepbound, I am loosing, 40 lbs so far with more to go. You may also need to readjust your expectations. Are you not loosing anything or just slowly! If you are worried about not enough pick up a LB of butter and see how that feels to carry around. Also you may need to look at your water, protein and fiber intake as well as total calories. I would see if your MD can recommend a nutritionist that might help or you may need to go up a dose.
Good luck!

August 7
A MyPsoriasisTeam Member

I took Taltz and Ozempic then Mounjaro for type 2 diabetes. I actually lost weight.

August 4
A MyPsoriasisTeam Member

I can answer for you as we all react differently but I am on Zepbound and Tremfya. I have lost 35 lbs and am 7.5 mg now. I am not interested in extreme weight loss, I have been steady but not enormous monthly losses. But as important to me my CRP dropped by 1/2, my A1C is now normal and not prediabetic and many other things are going in the right direction. Don’t measure yourself against someone else. But you need to be focused on Protein and fiber and get some activity in - walking helps esp after a meal a 10 min walk helps. But if you are losing and feeling better then celebrate that and realize your journey should not be compared to other people. Good Luck!

July 8
A MyPsoriasisTeam Member

Please invest some time into researching natural therapies for P and for Arthritis, DawnFisher. I have found that researching these things has helped me so much to minimize my conditions, and just recently bought Urea Cream to try on my feet.
I asked my Podiatrist about using it (only been using it for 2 days), and she said that it depends on the percentage. Mine is 2 % and she said that was ok to use, but only 2 days per week and not too much...use sparingly, because it thins the skin. I was grateful for her advice, so the rest of the week, I used very thick Sorbolene cream. This is keeping things under control....so I will post again when I've had more than a few weeks trialing this Urea cream. Oh, BTW, it makes your skin feel really nice too.

July 5

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Dallas, TX