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Isn't Biologics & Jaks, Two Different medications, that Works differently? Attacking different enities, different from one another, How diff

A MyPsoriasisTeam Member asked a question 💭
Oldtown, MD
July 7
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Can Biologics for Psoriasis Stop Working? Read Article...
MyPsoriasisTeam

Great question! Yes, biologics and JAK inhibitors are two distinct types of medications, and they work in quite different ways to manage psoriasis.

Biologics work *outside* the cell. They are proteins (made from living sources like human or animal cells) that target specific molecules — like TNF-alpha or interleukins — Show Full Answer

Great question! Yes, biologics and JAK inhibitors are two distinct types of medications, and they work in quite different ways to manage psoriasis.

Biologics work *outside* the cell. They are proteins (made from living sources like human or animal cells) that target specific molecules — like TNF-alpha or interleukins — that drive inflammation. Think of them as interceptors that grab and neutralize the "troublemakers" before they cause damage.

Because they're proteins, they get broken down in the stomach, so they must be given as injections or infusions — not swallowed as a pill. JAK inhibitors work *inside* the cell. JAK stands for Janus kinase — a type of enzyme inside cells that sends inflammation signals. JAK inhibitors block these internal signals from being passed along, essentially cutting off the communication chain that leads to inflammation.

A key difference is that JAK inhibitors can be taken as oral pills, making them more convenient for some people.

Here's a quick comparison:

- Biologics → target proteins *outside* cells (e.g., TNF-alpha, IL-17)
- JAK inhibitors → block signaling enzymes *inside* cells
- Biologics → injected or infused
- JAK inhibitors → usually taken by mouth

Both affect the immune system, so both carry an increased risk of infections. Always discuss the risks and benefits with a dermatologist to find the best fit for your situation.

July 7
A MyPsoriasisTeam Member

I am unable to reply it says unable to find page.this happened on !multiple
questions.I would like to answer the question on JAK meds thanks patty

July 8
A MyPsoriasisTeam Member

I'm told that Light Therapy works really well

July 17
A MyPsoriasisTeam Member

Hello Elizabeth, nice to meet 🤗I like your Awareness in things, kinda, like , The early bird catches the Worm, Be Prepared, that is what I try to live by. Becuz if you Stay prepared, then you don't have to Get prepared... I will admit, there are times I am not so prepared but I try. I do not like Health Surprises, though I have had Many, & they never seem to be that good. Elizabeth, I went off track, oops. You mentioned Skyrizi. Funny you said that one, hehe Here is Why. In 2019, I went on a Study & I was one of the patient to do so. It was SKYRIKI... Was on that for 4year, then another 2 followed. It was good on my Ps & to me, that was a Miracle, 1st time in my world of Clear Skin ,even though it did nothing for my PsA, they still continue me on the study For a total of 6years. So I am one of those Study Subjects & I loved it. The study did Everything, BW, testing, Every 3 months Full exams & compensated for it ; To boot. They paid for everything for my following 6years. I Felt like Well Taken Care of, a feeling not always felt , when dealing in the medical fields. So Elizabeth, my mother was named Elizabeth but they called her Rita, go figure 🤷🏼‍♀️thanks for viewing my responses & I love Hugs as much. Catchya later

July 8
A MyPsoriasisTeam Member

@TerryDesantis My understanding is that any, all, treatments may 'stop working.' Awfully discouraging. I am always intrigued by the claim that some of these biologics result in 75-90% clearer skin, and for some it lasts even 4-5 years. Think:: Skyrizi. Sometimes, I have been terribly disappointed that manufacturers will change the formula of a product that I had been successfully using -- Cerave Moisturizing Cream has added petrolatum, to which I am allergic. So far, I am able to use the formulas noted as specifically for psoriasis.

July 8

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