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Real members of MyPsoriasisTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
February 17
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A MyPsoriasisTeam Member

@Hummimgbird914 How did your appointment go? Did your rheumatologist agree to try something else?
That's unfortunate about your ex and Enbrel. But, like you said we are all different. I have had no problems with Enbrel and feel like it basically controls the PsA for me. Once in a while I'll get an ache but I don't have that feeling that my body is destroying itself ..in fact, I feel pretty damn good!

March 13
A MyPsoriasisTeam Member

@A MyPsoriasisTeam Member. I am afraid to try Enbrel because my ex-husband had a horrible side affect from it. It caused pustular psoriasis with other pretty severe symptoms. I know that no two people are the same and most likely not experience the same symptoms, so maybe I really need to read up on it for myself. Right now, I am looking at Bimzelx. I am going to take my next scheduled dose of Taltz on the 26th just in case it may be helping in the smallest way, but I have an appointment with my rheumatologist on March 12th, and I will let her know I want to try another biologic in hopes it will make a difference. Something has to help me. I swear I can feel this disease eating away at my body continuing to cause more & more irreversible damage. It's been active for more than 20 plus years. Who knows....probably my entire life of 65 years. Obviously, I was born with it but never knew until I was 62 years old. Just shoot me...🤪

February 23
A MyPsoriasisTeam Member

You have tried a lot, Hummingbird914!!!
I lucked out and my first one worked...Enbrel. It has changed my life! I was just thinking about how I just wrapped up 2 full years with no major flares, no swollen knees, ankles, or feet. I was a teenager since the last time I went this long being able to walk, and I turn 50 this year.

February 20
MyPsoriasisTeam

What biologic options are available after trying Humira, Cosentyx, Orencia, and Taltz for psoriatic arthritis affecting the feet?

Since you've tried TNF inhibitors (Humira), IL-17 inhibitors (Cosentyx, Taltz), and a T-cell inhibitor (Orencia) without success, there are still several biologic options to discuss with your Show Full Answer

What biologic options are available after trying Humira, Cosentyx, Orencia, and Taltz for psoriatic arthritis affecting the feet?

Since you've tried TNF inhibitors (Humira), IL-17 inhibitors (Cosentyx, Taltz), and a T-cell inhibitor (Orencia) without success, there are still several biologic options to discuss with your doctor:

IL-23 inhibitors you haven't tried yet:
- Tremfya (guselkumab)
- Skyrizi (risankizumab)
- Stelara (ustekinumab) - blocks both IL-12 and IL-23

Other TNF inhibitors:
- Cimzia (certolizumab pegol)
- Simponi (golimumab)
- Remicade (infliximab)
- Enbrel (etanercept)

Newer option:
- Bimzelx (bimekizumab) - another IL-17 inhibitor

Your doctor might also consider adding a conventional DMARD like methotrexate to work alongside a biologic, or switching to a different drug class entirely, such as JAK inhibitors.

Finding the right treatment often takes several tries. A MyPsoriasisTeam member shared they're "praying to find the right meds that will work long term" after having several work briefly then stop. Don't lose hope - there are still options to explore with your rheumatologist.

February 17

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